Graves Ophthalmopathy: Comparison of Clinical Appearance, Thyroid Hormones, and TSH Receptor Antibody Profiles

Imam Subekti
April 2018  •  DOI: 10.23886/ejki.6.9299.


Graves ophthalmopathy (GO) is the most common extrathyroid manifestation of Graves’ disease (GD). This study aims to evaluate characteristic difference in terms of clinical appearance, thyroid hormones (TSHs, FT4 and FT3) and TSH receptor antibody profiles (TRAb and TSAb) in GD patients with and without clinical GO. This study using consecutive sampling methode on endocrine clinic dr. Cipto Mangunkusumo National Hospital in December 2009 to Januari 2011. This was cross sectional study involving 75 GD patients. Subjects were divided into two groups, those with and without clinical OG. Graves ophthalmopathy were diagnosed clinically by Bartley’s criteria. Thyroid hormones (TSHs, FT4 and FT3) and TRAb were measured by ELISA technique while TSAb were measured by RIA technique. There was no statistically significant difference in smoking history, blood pressure, age, and duration of illness between two groups. In terms of laboratory parameters, there were also no significant difference of TSHs, FT4, FT3, TRAb and TSAb between groupswith and without clinical GO. The clinical OG group however, showed increasing trend of TSAb than those of without clinical OG (615.4 (295-1120.9) vs 972.4 (450-1648), p=0.06). If lower lid retraction were included as diagnosis of OG, there was significant difference of TSAb between two groups (596 [291-1120] vs 941 [454-1642], p=0.03). There were no significant difference in clinical appearances, thyroid hormones and anti-TSH receptor antibody profiles between GD patients with and without clinical GO. But there was incraesing tren of TSAB in GD patients with clinical GO.

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