Singawalang Leaf Extract Effects on LDL Levels of Hypercholesterolemic Male Rats

Claudi Artha
Arifa Mustika
Sri Wijayanti Sulistyawati
August 2017  •  DOI: 10.23886/ejki.5.7151.


Petiveria Alliaceae or known as singawalang can decrease levels of LDL cholesterol in the blood because of the content of compounds such as flavonoids, alkaloids, and tannins. This study is a laboratory experimental research with pre and posttest control group design. Sample using rats (Rattus norvegicus) males, aged 2-3 months with body weight ± 150 gs. The average LDL cholesterol level of negative control group (KN) is 3.40 ± 2.07, which means there is no significant increase. In the simvastatin group (S), the treatment group 1 (K1), group 2 (K2), and treatment group 3 (K3) the average of LDL cholesterol results showed a decrease with the result S = -71.10 ± 31.35, K1 = -53.60 ± 26.80, K2 = -67.05 ± 23.98, and K3 = -51.06 ± 20.27. By using One Way Anova obtained significance value of p <0.05, which showed significant differences between group KN with group S, K1, K2, K3.

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