PRODIA EDUCATION AND RESEARCH INSTITUTE (PERI)

Association of Fat Mass and Obesity-associated Gene (FTO) Rs9939609 Variant with Early Onset Obesity Among Bataknese and Chinese Children in Indonesia: a Case-control Study

background: childhood obesity is associated with the risk of adult obesity and obesity-related chronic disease. the fat mass and obesity-associated gene (fto) rs9939609 variant are of particular inter...


Diagnostic Test Equivalent Hemoglobin Reticulocyte in Iron Deficiency Anemia

background: diagnosing iron deficiency anemia (ida) is easy, but also can be complicated in condition with inflammation. a new modality for diagnostic which isn't influenced with inflammation is neede...


The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar

background: type 2 diabetes mellitus (dm) is one of dominant factors in cardiovascular deaths and induces endothelial dysfunction. a definite sign of endothelial dysfunction is foam cells formation de...


Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells

background: caffeic acid has been shown to induce apoptosis in mg63 osteosarcoma cells. along with the apoptotic induction, caffeic acid was shown to activate caspase-8, -9 and -3. however, the role o...


Telomere in Aging and Age-Related Diseases

background: the number of elderly population in the world keep increasing. in their advanced ages, many elderly face years of disability because of multiple chronic diseases, frailty, making them lost...


Antioxidant Activity of Phyllanthus Niruri Extract, Rutin and Quercetin

background: normal metabolism of oxygen and exogenous factors constantly generate free radicals which could be harmful to the human body. human need antioxidants to provide protection against free rad...


Busulfan Treatment Effects on Testicular Tissue and Serum Levels of Anti- Mullerian Hormone and Testosterone in Adult Mice

background: busulfan, a chemotherapeutic drug, is an alkylating antineoplastic agent that belongs to the class of alkyl sulfonates and has some side effects on fertility. this research was aimed to in...


DNA Sequence Analysis of DtxR Gene (Partial) of Corynebacterium Diphtheriae Causing Diphtheria in Jawa and Kalimantan Islands, Indonesia

background: dtxr gene is a global regulator that can be used as a marker for detection of corynebacterium diphtheriae (c. diphtheriae) and it is also a representative tool for mapping purpose (molecul...


Early Screening of Hemoglobinopathy in Indonesia Using Erythrocyte Indices

background: the mutation spectrums of hemoglobinopathy are different among populations that yield a different result of erythrocyte indices. calculation of erythrocyte indices with some formula has be...


Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) as a Therapeutical Target in Type-2 Diabetes Mellitus: a Review

background: increasing free radicals and oxidative stress due to chronic hyperglycemia in type-2 diabetes mellitus (dm) promotes the activity of endogenic antioxidative genes. nuclear factor erythroid...


Growth and Osteogenic Differentiation of CD117+ Dental Pulp and Periodontal Ligament Cells

background: dental pulp stem cell (dpsc) and periodontal ligament stem cell (pdlsc) have been suggested as valuable seed cells for bone engineering, suggesting that both stem cells are potential osteo...


The Immunobiology of Cancer: an Update Review

background: the introduction of mechanism based targeted therapies to treat human cancers has been pledge as one of the results of three decades of remarkable progress of research into the mechanisms ...


Cytotoxicity of Alpinia Galanga Rhizome Crude Extract on NIH-3T3 Cells

background: alpinia galanga (a. galanga) was reported as a potential medicinal source due to its wide effect. a. galanga rhizome crude extract (arce) was reported to have high cytotoxic effect in canc...


Correlation Abnormal Ankle-Brachial Index and Multivessel Coronary Artery Disease in Acute Coronary Syndrome Patients

background: many studies showed the association between peripheral artery disease (pad) and coronary artery disease (cad). the anklebrachial index (abi) was a simple, noninvasive, and not expensive te...


The Association Between Cardiovascular Risk and Elevated Triglycerides

background: the association between elevated triglycerides and cardiovascular risk has been extensively studied. the elevated level of triglycerides occurs through abnormalities in hepatic very low-de...


Differences in the Effect of Using Sterile Water for Irrigation and Normal Saline Washing to Peritoneal Adhesion Post-Laparotomy on White Rats

background: peritoneal adhesion is a side effect of abdominal surgery that often occurs. many efforts were made in abdominal surgery to prevent or minimize the occurrence of this adhesion. one way to ...


Comparison of Transforming Growth Factor-Beta 1 Concentration in Preeclampsia and Normal Pregnancy Women

background: according to the theory of endothelial dysfunction, the pathogenesis of preeclampsia is associated with the imbalance of angiogenic and anti-angiogenic factors. transforming growth factor-...


Genome Editing with Crispr-Cas9 Systems: Basic Research and Clinical Applications

background: recently established genome editing technologies will open new avenues for biological research and development. human genome editing is a powerful tool which offers great scientific and th...


The Correlation Between TP53 Expression and Ki-67 Proliferation with Bartl Malignancy Degree of Plasma Cell Neoplasm

background: plasma cell neoplasm (pcn) is a neoplastic plasma cell proliferation which includes solitary bone plasmacytoma (sbp), extramedullary plasmacytoma (emp) and multiple myeloma (mm). bartl cla...


The Blockade of Glutamate N-methyl-D-aspartate Receptors Into the Prelimbic of Prefrontal Cortex Decreases Morphine-induced Conditioned Place Preference in Rat

background: the prelimbic area (pl) of the prefrontal cortex is susceptible to abnormal developmental stimuli that raises the risk of addiction. glutamate receptors play a key role in opiate reinforce...


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